Deltacortene prednisone

   

Deltacortene.
A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. [PubChem]
Deltacortene, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Deltacortene has very little mineralocorticoid activity.
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or measles. Patients should also be advised if they are exposed, medical advice should be sought without delay.
The pharmacokinetic interactions listed below are potentially clinically important. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance. Therefore, the dose of corticosteroid should be titrated to avoid steroid toxicity. Corticosteroids may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia. The effect of corticosteroids on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulants when given concurrently with corticosteroids. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.
Systemic fungal infections and known hypersensitivity to components.
Deltacortene Indication: For the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison’s disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis, Crohn’s disease, acquired hemolytic anemia, congenital hypoplastic anemia, erythroblastopenia, adult secondary thrombocytopenia, adult idiopathic thrombocytopenia purpura, acute or subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute or chronic lymphocytic leukemia, Hodgkin’s or non-Hodgkin’s lynphomas, Waldenstrom’s macroglobulinemia, primary brain tumors (adjunct), nephrotic syndrome, tuberculous meningitis, multiple sclerosis, myasthenia gravis. cerebral edema, chorioretinitis, diffuse posterior choroiditis, aleergic conjunctivitis, Herpes zoster ophthalmicus, anterior segment inflammation, iridocyclitis, iritis, keratitis, optic neuritis, sympathetic ophthalmia, corneal marginal allergic ulcers, symptomatic sarcoidosis, Loeffler’s syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy and aspiration pneumonitis.
Mechanism Of Action: Deltacortene is a glucocorticoid agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Drug Interactions: Itraconazole The imidazole increases the effect and toxicity of the corticosteroid.
Ketoconazole The imidazole increases the effect and toxicity of the corticosteroid.
Ethotoin The enzyme inducer decreases the effect of the corticosteroid.
Fosphenytoin The enzyme inducer decreases the effect of the corticosteroid.
Mephenytoin The enzyme inducer decreases the effect of the corticosteroid.
Phenytoin The enzyme inducer decreases the effect of the corticosteroid.
Rifampin The enzyme inducer decreases the effect of the corticosteroid.
Ambenonium The corticosteroid decreases the effect of anticholinesterases.
Edrophonium The corticosteroid decreases the effect of anticholinesterases.
Neostigmine The corticosteroid decreases the effect of anticholinesterases.
Pyridostigmine The corticosteroid decreases the effect of anticholinesterases.
Trisalicylate-choline The corticosteroid decreases the effect of salicylates.
Salsalate The corticosteroid decreases the effect of salicylates.
Salicylate-magnesium The corticosteroid decreases the effect of salicylates.
Salicylate-sodium The corticosteroid decreases the effect of salicylates.
Aspirin The corticosteroid decreases the effect of salicylates.
Bismuth Subsalicylate The corticosteroid decreases the effect of salicylates.
Anisindione The corticosteroid alters the anticoagulant effect.
Dicumarol The corticosteroid alters the anticoagulant effect.
Acenocoumarol The corticosteroid alters the anticoagulant effect.
Warfarin The corticosteroid alters the anticoagulant effect.
Amobarbital The barbiturate decreases the effect of the corticosteroid.
Aprobarbital The barbiturate decreases the effect of the corticosteroid.
Butethal The barbiturate decreases the effect of the corticosteroid.
Butalbital The barbiturate decreases the effect of the corticosteroid.
Butabarbital The barbiturate decreases the effect of the corticosteroid.
Heptabarbital The barbiturate decreases the effect of the corticosteroid.
Hexobarbital The barbiturate decreases the effect of the corticosteroid.
Dihydroquinidine barbiturate The barbiturate decreases the effect of the corticosteroid.
Methohexital The barbiturate decreases the effect of the corticosteroid.
Methylphenobarbital The barbiturate decreases the effect of the corticosteroid.
Pentobarbital The barbiturate decreases the effect of the corticosteroid.
Phenobarbital The barbiturate decreases the effect of the corticosteroid.
Secobarbital The barbiturate decreases the effect of the corticosteroid.
Talbutal The barbiturate decreases the effect of the corticosteroid.
Primidone The barbiturate decreases the effect of the corticosteroid.
Quinidine barbiturate The barbiturate decreases the effect of the corticosteroid.
Chlorotrianisene The estrogenic agent increases the effect of corticosteroid.
Clomifene The estrogenic agent increases the effect of corticosteroid.
Diethylstilbestrol The estrogenic agent increases the effect of corticosteroid.
Estradiol The estrogenic agent increases the effect of corticosteroid.
Estriol The estrogenic agent increases the effect of corticosteroid.
Conjugated Estrogens The estrogenic agent increases the effect of corticosteroid.
Estrone The estrogenic agent increases the effect of corticosteroid.
Estropipate The estrogenic agent increases the effect of corticosteroid.
Ethinyl Estradiol The estrogenic agent increases the effect of corticosteroid.
Mestranol The estrogenic agent increases the effect of corticosteroid.
Midodrine Increased arterial pressure.
Quinestrol The estrogenic agent increases the effect of corticosteroid.
Food Interactions: Avoid alcohol.
Avoid taking with grapefruit juice.
Generic Name: Prednisone.
Synonyms: Prednisona [Inn-Spanish]; Prednisonum [Inn-Latin]; PRD; Dehydrocortisone.
Drug Category: Antineoplastic Agents; Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents.
Drug Type: Small Molecule; Approved.
Other Brand Names containing Prednisone: Delta-cortelan; Delta-cortisone; Delta-cortone; Delta-dome; Adasone; Ancortone; Apo-prednisone; Betapar; Bicortone; Cartancyl; Colisone; Cortan; Cortancyl; Cortidelt; Cotone; Dacorten; Dacortin; Decortancyl; Decortin; Decortisyl; Dekortin; Delcortin; Dellacort; Dellacort A; Delta Cortelan; Delta E; Deltacortene; Deltacortisone; Deltacortone; Deltasone; Deltison; Deltisona; Deltisone; Deltra; Di-Adreson; Diadreson; Econosone; Encorton; Encortone; Enkorton; Fernisone; Fiasone; Hostacortin; In-Sone; Incocortyl; Juvason; Lisacort; Me-Korti; Metacortandracin; Meticorten; Nisona; Nizon; Novoprednisone; Nurison; Orasone; Origen Prednisone; Panafcort; Panasol; Paracort; Parmenison; Pehacort; Precort; Predeltin; Prednicen-M; Prednicorm; Prednicort; Prednicot; Prednidib; Prednilonga; Prednison; Prednisone Intensol; Prednitone; Prednizon; Prednovister; Presone; Pronison; Rectodelt; Retrocortine; Servisone; Sone; Sterapred; Supercortil; Ultracorten; Ultracortene; Winpred; Wojtab; Zenadrid;
Absorption: Readily absorbed from the gastrointestinal tract.
Toxicity (Overdose): Not Available.
Protein Binding: Extensively bound to plasma proteins.
Half Life: 2 to 3 hours.
Dosage Forms of Deltacortene: Tablet Oral.
Chemical IUPAC Name: (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione.

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