MIN — what is Deltacortene used for, general information, pharmacology, Deltacortene for patients, Deltacortene interactions, Deltacortene contraindications, additional information about Deltacortene, deltacortene prednisone.

Deltacortene

A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. [PubChem]

Deltacortene, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Deltacortene has very little mineralocorticoid activity.

Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or measles. Patients should also be advised if they are exposed, medical advice should be sought without delay.

The pharmacokinetic interactions listed below are potentially clinically important. Drugs that induce hepatic enzymes such as phenobarbital, phenytoin and rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response. Drugs such as troleandomycin and ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance. Therefore, the dose of corticosteroid should be titrated to avoid steroid toxicity. Corticosteroids may increase the clearance of chronic high dose aspirin. This could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn. Aspirin should be used cautiously in conjunction with corticosteroids in patients suffering from hypoprothrombinemia. The effect of corticosteroids on oral anticoagulants is variable. There are reports of enhanced as well as diminished effects of anticoagulants when given concurrently with corticosteroids. Therefore, coagulation indices should be monitored to maintain the desired anticoagulant effect.

Systemic fungal infections and known hypersensitivity to components.

Deltacortene Indication: For the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison’s disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis, Crohn’s disease, acquired hemolytic anemia, congenital hypoplastic anemia, erythroblastopenia, adult secondary thrombocytopenia, adult idiopathic thrombocytopenia purpura, acute or subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute or chronic lymphocytic leukemia, Hodgkin’s or non-Hodgkin’s lynphomas, Waldenstrom’s macroglobulinemia, primary brain tumors (adjunct), nephrotic syndrome, tuberculous meningitis, multiple sclerosis, myasthenia gravis. cerebral edema, chorioretinitis, diffuse posterior choroiditis, aleergic conjunctivitis, Herpes zoster ophthalmicus, anterior segment inflammation, iridocyclitis, iritis, keratitis, optic neuritis, sympathetic ophthalmia, corneal marginal allergic ulcers, symptomatic sarcoidosis, Loeffler’s syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy and aspiration pneumonitis.

Mechanism Of Action: Deltacortene is a glucocorticoid agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Drug Interactions: Itraconazole The imidazole increases the effect and toxicity of the corticosteroid

Ketoconazole The imidazole increases the effect and toxicity of the corticosteroid

Ethotoin The enzyme inducer decreases the effect of the corticosteroid

Fosphenytoin The enzyme inducer decreases the effect of the corticosteroid

Mephenytoin The enzyme inducer decreases the effect of the corticosteroid

Phenytoin The enzyme inducer decreases the effect of the corticosteroid

Rifampin The enzyme inducer decreases the effect of the corticosteroid

Ambenonium The corticosteroid decreases the effect of anticholinesterases

Edrophonium The corticosteroid decreases the effect of anticholinesterases

Neostigmine The corticosteroid decreases the effect of anticholinesterases

Pyridostigmine The corticosteroid decreases the effect of anticholinesterases

Trisalicylate-choline The corticosteroid decreases the effect of salicylates

Salsalate The corticosteroid decreases the effect of salicylates

Salicylate-magnesium The corticosteroid decreases the effect of salicylates

Salicylate-sodium The corticosteroid decreases the effect of salicylates

Aspirin The corticosteroid decreases the effect of salicylates

Bismuth Subsalicylate The corticosteroid decreases the effect of salicylates

Anisindione The corticosteroid alters the anticoagulant effect

Dicumarol The corticosteroid alters the anticoagulant effect

Acenocoumarol The corticosteroid alters the anticoagulant effect

Warfarin The corticosteroid alters the anticoagulant effect

Amobarbital The barbiturate decreases the effect of the corticosteroid

Aprobarbital The barbiturate decreases the effect of the corticosteroid

Butethal The barbiturate decreases the effect of the corticosteroid

Butalbital The barbiturate decreases the effect of the corticosteroid

Butabarbital The barbiturate decreases the effect of the corticosteroid

Heptabarbital The barbiturate decreases the effect of the corticosteroid

Hexobarbital The barbiturate decreases the effect of the corticosteroid

Dihydroquinidine barbiturate The barbiturate decreases the effect of the corticosteroid

Methohexital The barbiturate decreases the effect of the corticosteroid

Methylphenobarbital The barbiturate decreases the effect of the corticosteroid

Pentobarbital The barbiturate decreases the effect of the corticosteroid

Phenobarbital The barbiturate decreases the effect of the corticosteroid

Secobarbital The barbiturate decreases the effect of the corticosteroid

Talbutal The barbiturate decreases the effect of the corticosteroid

Primidone The barbiturate decreases the effect of the corticosteroid

Quinidine barbiturate The barbiturate decreases the effect of the corticosteroid

Chlorotrianisene The estrogenic agent increases the effect of corticosteroid

Clomifene The estrogenic agent increases the effect of corticosteroid

Diethylstilbestrol The estrogenic agent increases the effect of corticosteroid

Estradiol The estrogenic agent increases the effect of corticosteroid

Estriol The estrogenic agent increases the effect of corticosteroid

Conjugated Estrogens The estrogenic agent increases the effect of corticosteroid

Estrone The estrogenic agent increases the effect of corticosteroid

Estropipate The estrogenic agent increases the effect of corticosteroid

Ethinyl Estradiol The estrogenic agent increases the effect of corticosteroid

Mestranol The estrogenic agent increases the effect of corticosteroid

Midodrine Increased arterial pressure

Quinestrol The estrogenic agent increases the effect of corticosteroid

Food Interactions: Avoid alcohol.

Avoid taking with grapefruit juice.

Generic Name: Prednisone

Synonyms: Prednisona [Inn-Spanish]; Prednisonum [Inn-Latin]; PRD; Dehydrocortisone

Drug Category: Antineoplastic Agents; Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents

Drug Type: Small Molecule; Approved

Other Brand Names containing Prednisone: Delta-cortelan; Delta-cortisone; Delta-cortone; Delta-dome; Adasone; Ancortone; Apo-prednisone; Betapar; Bicortone; Cartancyl; Colisone; Cortan; Cortancyl; Cortidelt; Cotone; Dacorten; Dacortin; Decortancyl; Decortin; Decortisyl; Dekortin; Delcortin; Dellacort; Dellacort A; Delta Cortelan; Delta E; Deltacortene; Deltacortisone; Deltacortone; Deltasone; Deltison; Deltisona; Deltisone; Deltra; Di-Adreson; Diadreson; Econosone; Encorton; Encortone; Enkorton; Fernisone; Fiasone; Hostacortin; In-Sone; Incocortyl; Juvason; Lisacort; Me-Korti; Metacortandracin; Meticorten; Nisona; Nizon; Novoprednisone; Nurison; Orasone; Origen Prednisone; Panafcort; Panasol; Paracort; Parmenison; Pehacort; Precort; Predeltin; Prednicen-M; Prednicorm; Prednicort; Prednicot; Prednidib; Prednilonga; Prednison; Prednisone Intensol; Prednitone; Prednizon; Prednovister; Presone; Pronison; Rectodelt; Retrocortine; Servisone; Sone; Sterapred; Supercortil; Ultracorten; Ultracortene; Winpred; Wojtab; Zenadrid;

Absorption: Readily absorbed from the gastrointestinal tract.

Toxicity (Overdose): Not Available

Protein Binding: Extensively bound to plasma proteins.

Half Life: 2 to 3 hours

Dosage Forms of Deltacortene: Tablet Oral

Chemical IUPAC Name: (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

Chemical Formula: C21H26O5

Prednisone on Wikipedia: http://en.wikipedia.org/wiki/Prednisone

Organisms Affected: Humans and other mammals

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