Prednisone for allergy dosage

   

prednisone (Rx)
Dosing & Uses.
tablet, delayed release.
5-60 mg/day PO in single daily dose or divided q6-12hr.
When converting from immediate-release to delayed-release formulation, note that delayed-release formulation takes about 4 hours to release active substances Note that exogenous steroids suppress adrenal cortex activity least during maximal natural adrenal cortex activity (between 4:00 and 8:00 AM)
Acute Asthma.
40-60 mg/day PO in single daily dose or divided q12hr for 3-10 days.
Giant Cell Arteritis.
40-60 mg PO qDay (1-2 years usual duration of treatment)
Idiopathic Thrombocytopenic Purpura.
Dose Tapering.
Day 1: 10 mg PO before breakfast, 5 mg after lunch and after dinner, and 10 mg at bedtime.
Day 2: 5 mg PO before breakfast, after lunch, and after dinner and 10 mg at bedtime.
Day 3: 5 mg PO before breakfast, after lunch, after dinner, and at bedtime.
Day 4: 5 mg PO before breakfast, after lunch, and at bedtime.
Day 5: 5 mg PO before breakfast and at bedtime.
Day 6: 5 mg PO before breakfast.
Rheumatoid Arthritis.
Immediate-release: ≤10 mg/day PO added to disease-modifying antirheumatic drugs (DMARDs)
Delayed-release: 5 mg/day PO initially; maintenance: lowest dosage that maintains clinical response; may be taken at bedtime to decrease morning stiffness with rheumatoid arthritis.
Advanced Pulmonary/Extrapulmonary Tuberculosis.
40-60 mg/day PO, tapered over 4-8 weeks.
Pneumocystis (carinii) jiroveci Pneumonia in Patients With AIDS (Off-label)
40 mg PO q12hr for 5 days, then 40 mg PO q24hr for 5 days, then 20 mg q24hr for 11 days.
Crohn’s Disease (Off-label)
40-60 mg PO qDay until resolution and resumption of weight gain (7-28 days usual duration)
Autoimmune Hepatitis.
60 mg PO qDay for 1 week; THEN 40 mg qDay for 1 week; THEN 30 mg qDay for 2 weeks; follow by 20 mg qDay; give half this dose if giving in combinaiton with azathioprine.
Administration.
Take with meal or snack.
High-dose glucocorticoids may cause insomnia; immediate-release formulation is typically administered in morning to coincide with circadian rhythm.
Delayed-release formulation takes about 4 hours to release active substances; thus, with this formulation, timing of dose should take into account delayed-release pharmacokinetics and disease or condition being treated (eg, may be taken at bedtime to decrease morning stiffness with rheumatoid arthritis)
Dosage Forms & Strengths.
tablet, delayed release.
Inflammation.
0.5-2 mg/kg/day PO in single daily dose or divided q12hr; not to exceed 80 mg/day.
Acute Asthma.
<12 years: 1-2 mg/kg/day PO in single daily dose or divided q12hr for 3-10 days; not to exceed 80 mg/day.
≥12 years: 40-60 mg/day PO in single daily dose or divided q12hr for 3-10 days.
Nephrotic Syndrome.
2 mg/kg/day PO; not to exceed 80 mg/day.
Pneumocystis (carinii) jiroveci Pneumonia in Patients With AIDS (Off-label)
<12 years: 1 mg/kg PO q12hr for 5 days, then 0.5-1 mg/kg q12hr for 5 days, then 0.5 mg/kg q24hr for 11-21 days.
>12 years: 40 mg PO q12hr for 5 days, then 40 mg PO q24hr for 5 days, then 20 mg q24hr for 11 days.
Interactions.
Interaction Checker.
Contraindicated.
Serious – Use Alternative.
Significant – Monitor Closely.
Adverse Effects.
Frequency Not Defined.
Allergic: Anaphylaxis, angioedema.
Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture after recent myocardial infarction, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis.
Dermatologic: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scalp, edema, facial erythema, hyper- or hypopigmentation, impaired wound healing, increased sweating, petechiae and ecchymoses, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria.
Endocrine: Abnormal fat deposits, decreased carbohydrate tolerance, development of cushingoid state, hirsutism, manifestations of latent diabetes mellitus and increased requirements for insulin or oral hypoglycemic agents in diabetics, menstrual irregularities, moon facies, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in children.
Fluid and electrolyte disturbances: Fluid retention, potassium loss, hypertension, hypokalemic alkalosis, sodium retention.
Gastrointestinal: Abdominal distention, elevation of serum liver enzymes levels (usually reversible upon discontinuance), hepatomegaly, hiccups, malaise, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, ulcerative esophagitis.
General: Increased appetite and weight gain.
Metabolic: Negative nitrogen balance due to protein catabolism.
Musculoskeletal: Osteonecrosis of femoral and humeral heads, Charcot-like arthropathy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures.
Neurologic: Arachnoiditis, convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri; usually following discontinuance of treatment), insomnia, meningitis, mood swings, neuritis, neuropathy, paraparesis/paraplegia, paresthesia, personality changes, sensory disturbances, vertigo.
Ophthalmic: Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, central serous chorioretinopathy.
Reproductive: Alteration in motility and number of spermatozoa.
Contraindications.
Untreated serious infections.
Administration of live or attenuated live vaccine (Advisory Committee on Immunization Practices (ACIP) and American Academy of Family Physicians (AAFP) state that administration of live virus vaccines usually is not contraindicated in patients receiving corticosteroid therapy as short-term (<2 weeks) treatment, in low-to-moderate dosages, as long-term alternate-day treatment with short-acting preparations, or in maintenance of physiologic dosages, such as, replacement therapy)
Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing syndrome, and hyperglycemia.
Prolonged use associated with increased risk of infection; monitor.
Use with caution in cirrhosis, ocular herpes simplex, hypertension, diverticulitis, hypothyroidism, myasthenia gravis, peptic ulcer disease, osteoporosis, ulcerative colitis, psychotic tendencies, renal insufficiency, pregnancy, diabetes mellitus, congestive heart failure, thromboembolic disorders, GI disorders.
Long-term treatment associated with increased risk of osteoporosis, myopathy, delayed wound healing.
Patients receiving corticosteroids should avoid chickenpox or measles-infected persons if unvaccinated.
Latent tuberculosis may be reactivated (patients with positive tuberculin test should be monitored)
Some suggestion (not fully substantiated) of slightly increased cleft palate risk if corticosteroids are used in pregnancy.
Methylprednisolone is preferred in hepatic impairment because prednisone must be converted to prednisolone in liver.
Prolonged corticosteroid use may result in elevated intraocular pressure, glaucoma, or cataracts.
May cause impairment of mineralocorticoid secretion; administer mineralocorticoid concomitantly.
May cause psychiatric disturbances; monitor for behavioral and mood changes; may exacerbate pre-existing psychiatric conditions.
Monitor for Kaposi sarcoma.
Pregnancy & Lactation.
Pregnancy category: C (immediate release); D (delayed release)
Drug may cause fetal harm and decreased birth weight; maternal corticosteroid use during first trimester increases incidence of cleft lip with or without cleft palate.
Lactation: Of maternal serum metabolites, 5-25% are found in breast milk; not recommended, or, if benefit outweighs risk, use lowest dose.
Pregnancy Categories.
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA: Information not available.
Pharmacology.
Mechanism of Action.
Glucocorticosteroid; elicits mild mineralocorticoid activity and moderate anti-inflammatory effects; controls or prevents inflammation by controlling rate of protein synthesis, suppressing migration of polymorphonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level; in physiologic doses, corticosteroids are administered to replace deficient endogenous hormones; in larger (pharmacologic) doses, they decrease inflammation.
Absorption.
Duration: Plasma, 60 min; biologic, 8-36 hr.
Peak plasma time: PO (immediate release), 2 hr; PO (delayed release), 6.0-6.5 hr.
Distribution.
Protein bound: 65-91%
Metabolism.
Extensively metabolized in liver; hydroxylated to active metabolite; conversion can be impaired in liver disease.
Metabolite: Prednisolone (active)
Elimination.
Half-life: 2.6-3 hr.
Dialyzable: Hemodialysis, no.
Excretion: Urine (mainly)
Patient Handout.
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
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